Elim Biopharm

Bioanalytical Services

Let us help you with your sensitive assays. You can count on Elim to support your time-sensitive drug development efforts from preclinical through clinical trials.

Elim’s Unprecedented Combination of

Quality, Speed and Cost Advantage

Elim provides high quality bioanalytical services to support your research and development needs. Current Elim customers know that high quality and great turnaround time is our specialty. Let us meet all of your bioanalytical and mass spec needs and relax, knowing that your results will be reliable, and delivered in time.

  • BA of Small Molecules
  • Quantification of Proteins & Large Molecules
  • Dry Blood Spot Analysis using AB Sciex QTrap 6500 LCMSMS
Our multiple analytical platforms including HPLC, LC/MS/MS, modern on-and off-line sample preparation techniques and high throughput robotics, allow Elim to support clinical and non-clinical drug development studies.

Try Elim’s Bioanalytical and Mass Spec services, and become one of Elim’s thousands satisfied customers. Let us help you accomplish your studies better and faster.

Try and Witness the Difference!

Try Elim’s Bioanalytical and Mass Spec services, and become one of Elim’s thousands satisfied customers. Let us help you accomplish your studies better and faster. We look forward to working with you!

To inquire about Elim’s Bioanalytical services, please contact us through Email (BA@Elimbio.com) or call us (800-214-7722 or 510-783-1112) with your project’s specific needs.

DNA Bioanalytical Services

Key Benefits

Our Team

Highly Qualified Expertise for Bioanalytical Services — Our Senior Leadership has:

  • More than 20 years expertise in the field of LCMSMS technology for both small and large molecules
  • Eighteen years of service lab experience including 15 years bioanalytical lab operation and senior level management in GLP regulated contract research organizations ( CRO )
  • More than 100 publications in peer-reviewed journals and scientific conferences
  • Numerous bioanalytical report preparations and reviews for FDA submission
  • Ph.D. in Analytical Medicinal Chemistry

Rapid Turnaround and High-Throughput

Rapid biological sample analysis is provided to support your time-sensitive drug development efforts, from discovery to preclinical studies, and through all phases of clinical trials. Our high-throughput Bioanalytical service supports drug discovery screening and lead optimization, including in vitro ADME, metabolic stability, CYP inhibition, and in vivo pharmacokinetic screening.

The Highest Quality Across Multiple Analytical Platforms

We provide clients with superior services while meeting their high quality standards and expectations. We use the industry’s standard LC/MS/MS system, HPLC, and auto-sampler (21 CFR Part 11 compliant software), and have high throughput robotics supporting automated large scale sample handling. With modern on- and off-line sample preparation techniques and bioanalytical services supervised by our senior leadership in Bioanalytical Services with over 20 years of expertise, we can deliver the quality and speed you need, every time.

A Full Range of

Bioanalytical Services

 

Analysis

Analysis of small molecules, metal complexes, proteins, peptides, oligonucleotides and PEG compounds

Analysis of Samples in Different biological matrices

  • Dry Blood Spot, Plasma, urine and tissues from various species
  • Support for PK, PD, Toxicokinetics, ADME and metabolite ID studies
  • For drug discovery, preclinical and clinical developments

Biomarker Assays

For drug safety and efficacy, diagnostics, disease modeling and clinical studies

Dry Blood Spot (DBS) Mass Spec Analysis

What is DBS for LC/MS/MS bioanalysis?

Spot 10 – 20 uL blood on coated card, dry, ship and store. For DMPK / TK bioanalysis, punch out the DBS disc, extract analytes and run LC/MS/MS to get analyte concentrations in blood.

What are the DBS advantages?

The Dry Blood Spot (DBS) advantages include:

  • Reduce blood volume and more time points / animal
  • Eliminate freezing sample for storage and shipping, and no freeze/thaw stability issue
  • Eliminate enzymatic degradation
  • Tolerate blood anticoagulant, temperature differences and pipetting variation
  • Increase biosafety with card coating matrices to kill bacteria and viruses
  • Simplify and reduce cost for global sample shipping and handing

What are the limits for DBS?

DBS is not for volatile analytes. Sensitivity is the main challenge for bioanalysis of DBS samples due to reduced blood volume in 10-20 uL. At Elim, we utilize the most sensitive LCMSMS system, AB Sciex Qtrap 6500, to analyze DBS samples.

Elim has the fastest turnaround times in the industry. However, the specific time required for a study will depend on the specifics of your sample and the scope and scale of the study.

Bioanalytical & Mass Spec FAQs

What are the advantages of dry blood spot (DBS)?

The Dry Blood Spot(DBS) advantages include

  • Reduce blood volume and more time points / animal
  • Eliminate freezing sample for storage and shipping, and no freeze / thaw stability issue
  • Eliminate enzymatic degradation
  • Tolerate blood anticoagulant, temperature differences and pipetting variation
  • Increase biosafety with card coating matrices to kill bacteria and viruses
  • Simplify and reduce cost for global sample shipping and handling

Sensitivity is the challenge for bioanalysis of DBS samples due to reduced blood volume in 10-20 uL. At Elim, we utilize the most sensitive LCMSMS system, AB Sciex Qtrap 6500, to analyze DBS samples.

What kind of BA and Mass Spec services do you offer?

We offer a full range of Bioanalytical services using cutting-edge LCMSMS technology. This includes small molecule quantification and large molecule quantification from a variety of biological matrices. Please click here for a full description of our BA and Mass Spec services.

Is your Staff experienced in BA services?

Yes. Our team consists of highly experienced senior leadership with the best industrial bioanalytical experience and well trained bioanalytical chemists. Our senior leader has performed large-scale Bioanalytical studies in GLP regulated contract research organizations (CRO), produced numerous bioanalytical reports and reviews for FDA submission.

What Instruments are you using for your Bioanalytical Services?

We use cutting-edge instrumentations, including the industry’s leading LCMSMS and a variety of supporting automations for large scale sample handling.

What studies can you do?

We support PK, PD, Toxicokinetics, ADME and metabolite ID studies for drug discovery, preclinical and clinical developments. We also work on samples from a variety of other sources including clinical and food samples.

Do you perform biomarkers studies?
Yes. We support biomarker assays and quantifications for drug safety and efficacy, diagnostics, disease modeling, and clinical studies.
How fast is your turn around time for Bioanalytical studies?
Elim has the fastest turnaround times in the industry. However, the specific time required for a study will depend on the specifics of your sample and the scope and scale of the study. A small bioanalytical study with limited sample quantity can be turned around as fast as overnight.